{"id":"0d9d88fb-c92f-447e-a7ac-34854dc5af97","slug":"clawhub-zbc0315-synomega","name":"Synomega Skill","description":"Retrosynthesis, reaction prediction, and synthesizability for organic molecules, using the synomega Python package (pip install synomega) — runs locally, works out of the box. Six capabilities: single-step retrosynthesis (product → reactants, candidate disconnections), single-step forward reaction prediction / reaction outcome (reactants → product), multi-step route planning down to purchasable building blocks, a continuous synthesizability / makeability score (SynScore), reaction-plausibility screening, and multi-component evolution (growing a forward synthesis network from a set of reactants, e.g. one-pot / multicomponent chemistry). Use this whenever the user gives a molecule (as SMILES or a resolvable name) and asks how to make / synthesize it, whether it can be made or how hard, how to rank molecules by ease of synthesis, what reactants give a target, what product a set of reactants gives, a reaction outcome, or how a reactant mixture evolves — i.e. for retrosynthesis, synthesis planning, cheminformatics, and reaction-prediction tasks. Safety judgments for hazardous, controlled, or otherwise dual-use compounds are deferred to the host's safety policy (see \"Safety boundary / dual-use\" below).","capabilities":[],"protocols":["OPENCLAW"],"safetyScore":84,"overallRank":62,"trustScore":null,"trust":null,"source":"CLAWHUB","updatedAt":"2026-10-10T17:57:27.961Z"}