Xpersona
agentCLAWHUBUnverified

Synthesis Evaluation

Synthesis evaluation workflows combining SynFormer-ED, Retrosynthesis Planner, and SAScore through SciMiner.

OpenClaw
View on ClawHubHomepage

Rank

62

Safety

84

Downloads

1.1k

Updated

Oct 11, 2026

Version

1.0.4

Source

CLAWHUB

About

What it does, and when to use it.

Capability contract not published. No trust telemetry is available yet. 1.1K downloads reported by the source. Last updated 10/11/2026.

Avoid when

  • Contract metadata is missing or unavailable for deterministic execution.

Risk flags: missing_or_unavailable_contract, trust_data_unavailable, schema_references_missing

Public facts

Every fact links back to the source it came from.

Vendor
Clawhubvendor · observed Oct 11, 2026
Protocol compatibility
OpenClawcompatibility · observed Oct 11, 2026
Adoption signal
1.1K downloadsadoption · observed Oct 11, 2026
Latest release
1.0.4release · observed May 31, 2026
Handshake status
UNKNOWNsecurity

Install and run

Setup complexity: low.

clawhub skill install s170qp1q4twz35wa85ppa8894h83w461:synthesis-evaluation
  1. Install using `clawhub skill install s170qp1q4twz35wa85ppa8894h83w461:synthesis-evaluation` in an isolated environment before connecting it to live workloads.
  2. No published capability contract is available yet, so validate auth and request/response behavior manually.
  3. Review the upstream CLAWHUB listing at https://clawhub.ai/sciminer/synthesis-evaluation before using production credentials.

Contract: missing

curl -s "https://www.xpersona.co/api/v1/agents/clawhub-sciminer-synthesis-evaluation/snapshot"

Documentation

CLAWHUB

42,096 characters of source documentation, loaded on request.

Extracted files

3 files captured from the source.

SKILL.md

---
name: synthesis-evaluation
description: Synthesis evaluation workflows combining SynFormer-ED, Retrosynthesis Planner, and SAScore through SciMiner.
credential_files:
   - ~/.config/sciminer/credentials.json
---

# Retrosynthesis Skill

This skill groups synthesizable-molecule generation and retrosynthesis workflows, including:

- synthesizable analog generation with SynFormer-ED
- retrosynthetic route recommendation from target SMILES
- synthetic accessibility scoring from SMILES or uploaded files

## When to use this skill

- Generate synthesizable analogs from one or more target molecules
- Propose retrosynthetic routes for candidate molecules
- Quickly estimate whether a molecule is easy or difficult to synthesize
- Rank generated molecules before selecting candidates for route planning

## Workflow guidance

- Synthesizable analog generation -> `Synformer`
- Retrosynthetic route recommendation -> `Retrosynthesis Planner`
- Synthetic accessibility scoring -> `SAScore`
- End-to-end synthesis evaluation -> chain `Synformer`, `SAScore`, and `Retrosynthesis Planner`

## Prerequisites

1. Obtain a free SciMiner API key from `https://sciminer.tech/utility`.
2. Store it outside this repository at `~/.config/sciminer/credentials.json` with JSON shaped as `{"api_key":"your_api_key_here"}`.
3. For SciMiner calls, read the API key from `~/.config/sciminer/credentials.json` and send it as the `X-Auth-Token` header.
4. Never print, persist, or store the API key in prompts, logs, or repository files. Agents should remember only the credential file path.

If `~/.config/sciminer/credentials.json` is not available or does not contain an `api_key` field, stop and tell the user to obtain a free SciMiner API key from `https://sciminer.tech/utility` and store it in that file. Do not try to complete the task by switching to other tools or services.

## Authoritative tool-doc source (required)

The published Markdown files under `https://sciminer.tech/tool_api_files/` are
the single source of truth for `provider_name`, `tool_name`, allowed
`parameters`, file-upload behavior, request encoding, and the example
submission flow for this skill's included tools.

Use these SciMiner Markdown docs:

- `Synformer` -> `Synformer_api_doc.md`
- `Retrosynthesis Planner` -> `Retrosynthesis Planner_api_doc.md`
- `SAScore` -> `SAScore_api_doc.md`

The agent MUST:

1. Resolve the selected tool's Markdown file and read it before every
   invocation.
2. Never invent `provider_name`, `tool_name`, parameter names, enum values,
   upload-field names, content type, or submission flow from memory.
3. Extract and follow the selected doc section's exact:
   - Base URL
   - API endpoint
   - Content-Type
   - Authentication header
   - Tool Name
   - Method
   - Parameter table, including required fields and enum values
   - File-upload instructions and example code
4. Choose the correct section if the selected doc contains multiple tool
   variants, such as SMILES input vs file upload.

_meta.json

{
  "ownerId": "kn725br751g8y5tkj1h6d2krf58356et",
  "slug": "synthesis-evaluation",
  "version": "1.0.4",
  "publishedAt": 1780221743492
}

skill-card.md

## Description:

Synthesis evaluation workflows combining SynFormer-ED, Retrosynthesis Planner, and SAScore through SciMiner.

This skill is ready for commercial/non-commercial use.

## Publisher:

[sciminer](https://clawhub.ai/user/sciminer)

### License/Terms of Use:

MIT-0

## Use Case:

Developers, researchers, and cheminformatics users use this skill to generate synthesizable analogs, evaluate synthetic accessibility, and request retrosynthetic route recommendations through SciMiner workflows.

### Deployment Geography for Use:

Global

## Known Risks and Mitigations:

Risk: Mutable remote documentation can change the request payloads or invocation flow an agent follows.

Mitigation: Review the selected SciMiner documentation before use and prefer a version that pins reviewed endpoints and schemas locally.

Risk: The workflow uses a local SciMiner API key and may process user-provided files.

Mitigation: Store the API key outside the repository, avoid printing or persisting it, and use the skill only when the SciMiner documentation host is trusted.

## Reference(s):

- [ClawHub Skill Page](https://clawhub.ai/sciminer/skills/synthesis-evaluation)
- [SciMiner Tool API Files](https://sciminer.tech/tool_api_files/)
- [Synformer API Documentation](https://sciminer.tech/tool_api_files/Synformer_api_doc.md)
- [Retrosynthesis Planner API Documentation](https://sciminer.tech/tool_api_files/Retrosynthesis%20Planner_api_doc.md)
- [SAScore API Documentation](https://sciminer.tech/tool_api_files/SAScore_api_doc.md)

## Skill Output:

**Output Type(s):** [text, markdown, code, shell commands, configuration, guidance]

**Output Format:** [Markdown summaries with JSON task results and share URLs]

**Output Parameters:** [1D]

**Other Properties Related to Output:** [May include generated API request code, polling guidance, result summaries, and SciMiner share URLs.]

## Skill Version(s):

1.0.4 (source: server release evidence)

## Ethical Considerations:

Users should evaluate whether this skill is appropriate for their environment, review any generated or modified files before relying on them, and apply their organization's safety, security, and compliance requirements before deployment.

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Machine-readable data

The same record, as JSON, for agents and crawlers.

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      "confidence": "medium",
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  "events": [
    {
      "eventType": "release",
      "title": "Release 1.0.4",
      "description": "**Summary: Switches to using public Markdown docs as the only source of truth for tool invocation, and removes internal registry and scripting files.** - Skill now uses SciMiner's public Markdown documentation files as the authoritative reference for all tool invocation details and parameter requirements. - Removed internal registry and helper scripts (`scripts/__init__.py`, `scripts/sciminer_registry.py`) and the local `skill-card.md`. - All tool payloads, file uploads, and invocation flows must follow the published docs under `https://sciminer.tech/tool_api_files/`. - Updated workflow guidance to require live parsing of the appropriate Markdown API doc for each tool and input shape before every invocation; no more code-side abstraction or memory of registry structures. - Agents must cite the selected Markdown doc as payload source in summaries, and attach result `share_url` links in user responses. - Credential management instructions remain the same; guidance for API key handling and error on missing keys unchanged.",
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}

Record generated Oct 11, 2026.

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